MMP-13 Antibody

MMP-13 Antibodyis available at Gentaur for Next week Delivery.

Description: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-13 (also designated collagenase-3) is produced by breast carcinomas and degrades collagen type I, II, III.

Immunogen Sequence:Synthetic peptide surrounding amino acid 454 of rat MMP-13

Target Alternative Name:MMP13 , CLG3 , Collagenase 3 , Matrix metalloproteinase 13

Species Reactivities:Human, mouse, rat, horse, bovine

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Formulation:In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 5 mM EDTA and 0.03% proclin.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunohistochemistry

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Application And Usages:Western blotting (0.5-4 µg/ml), immunoprecipitation and Immunohistochemistry (works with paraffin imbedded sections). However, the optimal concentrations should be determined individually. The antibody recognizes the proenzyme (~60 kDa) and the cleaved fragments (34 kDa and 48 kDa) of MMP-13. Reactivity to other species has not been tested.

Handling:The antibody solution should be gently mixed before use.