MeCP2 polyclonal antibody

MeCP2 polyclonal antibodyis available at Gentaur for Next week Delivery.

Description: MeCP2 is a chromosomal protein with abundant binding sites in the chromatin. It belongs to the family of methyl CpG binding proteins which also comprises MBD1, MBD2, MBD3 and MBD4. MeCP2 can bind specifically to methylated promoters, thereby repressing transcription. This transcriptional repression is mediated through interaction with histone deacetylase and the corepressor SIN3A. MeCP2 also is essential for development. Mutations in MeCP2 are the cause of several types of mental retardation including Rett syndrome, a progressive neurological disorder that causes mental retardation in females and mental retardation syndromic X-linked type 13, and may also be involved in Angelman syndrome and susceptibility to some types of autism.

Immunogen Sequence:MeCP2 (Methyl-CpG-binding domain protein 2) synthetic peptide containing a sequence from the C-terminal conjugated to KLH

Target Alternative Name:AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RTS, RTT

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect MeCP2 in human samples.

Formulation:In PBS with 0.05% sodium azide and 0.05% ProClin 300.

Purification: Affinity Purified

Application:Western blot, ELISA, ChIP.

Positive Control:Western blot: Hela cells, ELISA: peptides, ChIP: U2OS cells.

Application And Usages:ChIP: 5 µg/ChIP, WB: 1:1000, ELISA: 1:1000

Handling:The antibody solution should be gently mixed before use.