LDHA Antibody (Center)

LDHA Antibody (Center)is available at Gentaur for Next week Delivery.

Description: L-Lactate dehydrogenase A chain (LDHA) is a member of the LDH/MDH superfamily and LDH family. It catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHA is localized primarily in muscle tissue and is part of the lactate dehydrogenase family. Mutations in LDHA have been linked to exertional myoglobinuria. LDH1 is decreased in essential thrombocythemia. LDHA is induced through a non-genomic pathway of estrogen action. Reduction in LDH-A activity results in stimulation of mitochondrial respiration and decrease of mitochondrial membrane potential. Mutations in LDHA have been associated with in LDHA are the cause of glycogen storage disease type 11 (GSD11) which is a metabolic disorder that results in exertional myoglobinuria, pain, cramps and easy fatigue.

Immunogen Sequence:This LDHA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the Central region of human LDHA.

Target Alternative Name:LDHA; L-lactate dehydrogenase A chain; Cell proliferation-inducing gene 19 protein; LDH muscle subunit; Renal carcinoma antigen NY-REN-59.

Species Reactivities:Human. Predicted cross reactivity with monkey, pig, rat and bovine samples.

Tag Line:Polyclonal Antibody to detect LDHA in human samples

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Application:Western blot, IHC, FACS.

Positive Control:Western blot: Ramos and A375 cell line lysates, IHC: skin tissue, FACS: HeLa cells

Application And Usages:Western blot: ~1:1000, IHC: ~1:50–1:100, FACS: ~1:10-1:50.

Handling:The antibody solution should be gently mixed before use.