LAMP-1 Antibody (Center)

LAMP-1 Antibody (Center)is available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). A protein recently found to be involved in autophagy, LAMP-2, is a highly glycosylated protein associated with the lysosome. LAMP-1 shares much homology to LAMP-2 and is thoμght to have overlapping functions. Mice lacking LAMP-1 had very minor defects compared to those deficient in LAMP-2 expression. However, the loss of both proteins resulted in embryonic lethality, sμggesting that each protein possesses some unique and necessary functions.

Immunogen Sequence:LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.

Target Alternative Name:LAMP-1, Lysosome associated membrane protein 1

Species Reactivities:Human, mouse, rat

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Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.

Purification: Affinity chromatography purified via peptide column.

Application:Western blot, Immunofluorescence, ELISA

Positive Control:Western Blot: EL4 cell lysate Immunofluorescence: Human colon tissue

Application And Usages:Western Blot: 1 - 2 μg/ml, Immunofluorescence: 20 μg/ml, ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.