Lamin A Antibody

Lamin A Antibodyis available at Gentaur for Next week Delivery.

Description: Lamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication and chromatin organization. Lamin A is specifically cleaved by caspase-6 and therefore serves as a marker for caspase-6 activation. During apoptosis the 70 kDa lamin A is cleaved to a large (40-45 kDa) and small (23 kDa) fragment. The cleavage of lamins results in nuclear disregulation and cell death.

Immunogen Sequence:Synthetic peptide surrounding amino acid 220 of human Lamin A

Target Alternative Name:LMNA, HGPS, EMD2, FPLD, CDCD1, LDP1, LGMD1B, IDC, Lamin-A/C, CDDC ,LMN1 , CMD1A, PRO1

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.2 mg/ml) affinity purified rabbit anti-Lamin A polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunohistochemistry

Positive Control:/

Application And Usages:Western blot analysis (0.5-4 µg/ml) and Immunohistochemistry (15-20 µg/ml). However, the optimal conditions should be determined individually. The antibody mainly detects full length (~70 kDa) and in a much lesser extent the cleaved fragments (45 kDa and 23 kDa) of Lamin A/C.

Handling:The antibody solution should be gently mixed before use.