HLA-DRA Antibody (Clone # 302CT2.3.2)

HLA-DRA Antibody (Clone # 302CT2.3.2)is available at Gentaur for Next week Delivery.

Description: Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in MHC II å/∫ dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, -DQ and -DP) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. HLA-B belongs to the HLA class I heavy chain paralogs. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. HLA-B and -C can form heterodimers consisting of a membrane anchored heavy chain and a light chain (∫-2-Microglobulin). Polymorphisms yield hundreds of HLA-B and -C alleles.

Immunogen Sequence:This HLA-DRA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 48-75 amino acids from human HLA-DRA.

Target Alternative Name:HLA-DRA; HLA-DRA1; HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA

Species Reactivities:Human.

Tag Line:Monoclonal Antibody to detect HLA DRA in human samples.

Formulation:Crude ascites with 0.09% (W/V) sodium azide.

Purification: N/A

Application:Western blot.

Positive Control:Western blot: ZR-75-1 cell lysate.

Application And Usages:WB: 1:500 – 1:16000.

Handling:The antibody solution should be gently mixed before use.