HK2 (Hexokinase II) (Center) Antibody

HK2 (Hexokinase II) (Center) Antibodyis available at Gentaur for Next week Delivery.

Description: In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III, and IV. Hexokinase is an allosteric enzyme inhibited by its product GLC-6-P. Hexokinase activity is involved in the first step in several metabolic pathways. HK3 is bound to the outer mitochondrial membrane. Its hydrophobic N-terminal sequence may be involved in membrane bindng. It is the predominant hexokinase isozyme expressed in insuline-responsive tissues such as skeletal muscle. The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated wiht the N-terminus. Althoμgh found in NIDDM patients, genetic variations of HK2 do not contribute to the disease.

Immunogen Sequence:Synthetic peptide selected from the 409 - 439 amino acids center region of human HK2.

Target Alternative Name:Hexokinase type II, HK II, Muscle form hexokinase

Species Reactivities:Human

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Formulation:100 µg (0.25 mg/ml) purified rabbit Ig polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Purification: Affinity purified

Application:ELISA, Western blot, Immunohistochemistry

Positive Control:Western Blot: A375 cell lysate Immunohistochemistry: Human cancer tissue

Application And Usages:The antibody can be used for ELISA (0.25 µg/ml), Western blotting (0.5 – 2.5 µg/ml) and Immunohistochemistry (2.5 – 5.0 µg/ml).

Handling:The antibody solution should be gently mixed before use.