Heme Oxygenase-2 Antibody

Heme Oxygenase-2 Antibodyis available at Gentaur for Next week Delivery.

Description: Heme oxygenase (HO) is a microsomal enzyme that oxidatively cleaves heme, a pro-oxidant, into carbon monoxide and biliverdin. Two heme oxygenase isozymes, termed HO-1 and HO-2, have been identified so far. At the amino acid level, HO-1 and HO-2 are 42% homologous. However, each isozyme is evolutionary highly conserved. HO-1 is the inducible form of the enzyme and is therefore also referred to as stress protein Hsp32. Expression of HO-1 can be induced by a variety of stimuli such as heme, metals, hormones, UV radiation and sulfhydryl depleting agents. In contrast, HO-2 is the constituitive form of the enzyme. It is not inducible by exogeneous stimuli and HO-2 is the most prevalent form in most tissues, except the spleen where HO-1 levels are predominant under normal conditions.

Immunogen Sequence:Synthetic peptide surrounding amino acid 34 of human HO-2

Target Alternative Name:HMOX2 , HO-2 ,HO2 , EC 1.14.99.3

Species Reactivities:Human, mouse, rat, monkey, hamster

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Formulation:30 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA, and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blotting, Immunoprecipitation, Immunohistochemistry

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml), in immunoprecipitation (20 µg/ml) and Immunohistochemistry (20 µg/ml, frozen section tested). However, the optimal concentrations should be determined individually. The antibody recognizes ~36 kDa Heme-Oxygenase-2 of human, mouse, rat, hamster, and monkey origins. Blocking peptide (Cat.# 3392BP-50) is available separately.

Handling:The antibody solution should be gently mixed before use.