H2Apan polyclonal antibody

H2Apan polyclonal antibodyis available at Gentaur for Next week Delivery.

Description: Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histones play a central role in the regulation of transcription, DNA repair, DNA replication and chromosomal stability. These different functions are established via a complex set of post-translational modifications which either directly or indirectly alter chromatin structure and DNA accessibility to facilitate transcriptional activation or repression or other nuclear processes.

Immunogen Sequence:KLH-conjugated synthetic peptide of Histone H2A containing an unmodified sequence from the C-terminal part of the protein.

Target Alternative Name:Histone H2A

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect H2Apan in human samples.

Formulation:In PBS with 0.05% sodium azide and 0.05% ProClin 300.

Purification: Affinity purified

Application:Western blot, ELISA, ChIP, Dot blot.

Positive Control:ELISA: Antigen, ChIP: HeLa cells, Dot blot: Histone Peptides.

Application And Usages:ELISA: 1:50, Dot Blot: 1:20,000, ChIP: 1-2 µg/ChIP.

Handling:The antibody solution should be gently mixed before use.