H mgB1 Antibody

H mgB1 Antibodyis available at Gentaur for Next week Delivery.

Description: Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced H mgB1 (released by necrosis) acts as a chemokine, disulfide H mgB1 (actively secreted) as a cytokine, and sulfonyl H mgB1 (released from apoptotic cells) promotes immunological tolerance.

Immunogen Sequence:Recombinant protein of human H mgB1

Target Alternative Name:High mobility group protein B1, High mobility group protein 1, H mg-1, H mg3, SBP-1

Species Reactivities:Human, mouse, rat

Tag Line:Polyclonal Antibody to detect H mgB1 in Human, mouse and rat samples

Formulation:50 µl purified antibody supplied in PBS containing 50% glycerol and 0.02% sodium azide

Purification: Affinity purified rabbit IgG

Application:Western Blot, Immunohistochemistry, Immunofluorescence

Positive Control:Western blot

Application And Usages:WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

Handling:The antibody solution should be gently mixed before use.