GSK-3α Antibody

GSK-3α Antibodyis available at Gentaur for Next week Delivery.

Description: Glycogen synthase kinase 3-alpha is a multifunctional protein serine kinase. GSK-3 phosphorylates and inactivates glycogen synthase. It has also been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate Cyclin D1 proteolysis and subcellular localization. GSK-3alpha (GSK-3α) regulates the production of amyloid-beta peptides, a major component of the plaques that accumulate with progression of Alzheimer's disease, by phosphorylating Tau proteins. This presents the possibility that defects in GSK-3 signaling can contribute to the onset of Alzheimer’s disease. GSK-3α can be phosphorylated by Akt at Ser21. This phosphorylation of GSK-3α negatively regulates its kinase activity.

Immunogen Sequence:Human recombinant GSK-3α (Cat # 7003)

Target Alternative Name:Serine/threonine-protein kinase GSK3A, GSK-3alpha, Glycogen synthase kinase-3, GSK-3 alpha

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect GSK-3α in human samples

Formulation:0.5 mg/ml of GSK-3α antibody in PBS, pH 7.2, 30% glycerol, 0.5% BSA, 0.5 mM EDTA and 0.03% proclin

Purification: Affinity Purified Antibody

Application:Western blot

Positive Control:Western Blot: 3T3 cell lysate

Application And Usages:Western blot: 1-4 µg

Handling:The antibody solution should be gently mixed before use.