FOXO3a Antibody

FOXO3a Antibodyis available at Gentaur for Next week Delivery.

Description: Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of a variety of cellular processes, including the cell cycle, apoptosis, DNA repair, stress resistance, and metabolism. FOXO proteins are negatively regulated by the phosphatidylinositol 3-kinase-Akt signaling pathway, which is activated by growth factors and cytokines. Recent studies indicate that the activities of FOXO proteins are also regulated by oxidative stress, which induces their phosphorylation, translocation to the nucleus, and acetylation-deacetylation. Similar to the tumor suppressor p53, FOXO is activated by stress and induces the expression of genes that contribute to cell-cycle arrest, sμggesting that it also functions as a tumor suppressor.

Immunogen Sequence:Synthetic peptide corresponding to residues on the C-terminus of human FOXO3a

Target Alternative Name:FOXO3A , 602681 , O43524 , AF6q21 , DKFZp781A0677 ,FKHRL1 , FKHRL1P2 , mgC12739 , mgC31925

Species Reactivities:Human, mouse

Tag Line:/

Formulation:30 µg (0.2 mg/ml) affinity purified rabbit anti-FOXO3a polyclonal antibody in phosphate-buffered saline (PBS) containing 0.5% BSA, 30% glycerol, and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). Jurkat cell lysate (Cat.# 2401-100) and rat liver or rat kidney tissue lysate can be used as a positive control. A ~75 kDa band should be detected.

Handling:The antibody solution should be gently mixed before use.