ETO polyclonal antibody

ETO polyclonal antibodyis available at Gentaur for Next week Delivery.

Description: ETO is a transcriptional regulator which belongs to the myeloid translocation gene family. ETO exerts its function by interaction with transcription factors bound to promoters and binding to histone deacetylases. It recruits a range of corepressors to facilitate transcriptional repression. The t (8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. This translocation produces a chimeric gene made up of the 5’-region of AML1 and the 3’-region of the ETO gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

Immunogen Sequence:Polyclonal antibody against human ETO using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.

Target Alternative Name:RUNX1T1, AML1T1, CBFA2T1, CDR, MTG8, ZMYND2

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect ETO in human samples.

Formulation:In PBS with 0.05% (W/V) sodium azide.

Purification: Whole Anti-Sera

Application:ELISA, ChIP.

Positive Control:ELISA: Peptides, ChIP: SKNO-1 cells.

Application And Usages:ChIP: 4 µl/ChIP, ELISA: 1:100.

Handling:The antibody solution should be gently mixed before use.