Cox-1 Antibody

Cox-1 Antibodyis available at Gentaur for Next week Delivery.

Description: COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Nonsteroidal anti-inflammatory drμgs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throμghout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis.

Immunogen Sequence:Synthetic peptide corresponding to residues surrounding amino acids 586 of mouse Cox-1

Target Alternative Name:Cyclooxygenase 1, PTGS1, PCOX1, COX-1, PGG/HS, PGHS1 , PGHS-1, PHS1 , COX1, PTGHS

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.2 mg/ml) immunoaffinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 50% glycerol, 1% BSA, and 0.02% sodium azide.

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunohistochemistry

Positive Control:IHC: Brain, Cortex

Application And Usages:Western blotting (1-4 µg/ml), immunoprecipitation, and Immunohistochemistry(5µg/ml). However, the optimal concentrations should be determined individually. The antibody recognizes 70 kDa COX-1 of human, mouse and rat origins. It does not cross-react with COX-2.

Handling:The antibody solution should be gently mixed before use.