cIAP-2/HIAP-1 Antibody

cIAP-2/HIAP-1 Antibodyis available at Gentaur for Next week Delivery.

Description: Apoptosis can be inhibited by a group of proteins called inhibitors of apoptosis (IAPs). These proteins contain a BIR (baculovirus IAP repeat) domain near the amino-terminus. The BIR domain can bind some caspases. Many members of the IAP family of proteins block proteolytic activation of caspase-3 and –7. For example, XIAP, cIAP-1 and cIAP-2 appear to block cytochrome c-induced activation of caspase-9, thereby preventing initiation of the caspase cascade. Since cIAP-1 and cIAP-2 were first identified as components in the cytosolic death domain-induced complex associated with the TNF family of receptors, they may inhibit apoptosis by additional mechanisms.

Immunogen Sequence:Synthetic peptide surrounding amino acid 510 of human cIAP-2

Target Alternative Name:CIAP2 , cIAP2 , IAP1, AIP1, HIAP-1, HIAP1, API2, C-IAP2 , hiap-1, HAIP1, MIHC, MALT2, BIRC3

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:30 µg (0.2 mg/ml) affinity purified rabbit anti-cIAP-2 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot, Immunohistochemistry

Positive Control:/

Application And Usages:Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Jurkat cell lysate can be used as a positive control.

Handling:The antibody solution should be gently mixed before use.