CD146/MCAM Antibody (CT)

CD146/MCAM Antibody (CT)is available at Gentaur for Next week Delivery.

Description: The CD146 antigen, also known as MCAM, is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. CD146 contains the characteristic immunoglobulin-like domains (V-V-C2-C2-C2), a transmembrane region and a short cytoplasmic tail. The CD146 expression is detected in endothelial cells in vascular tissue throughout the body, and plays a role in cell adhesion, as well as in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. As a Ca2+-independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor, CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. CD146 is expressed predominantly on metastatic lesions and advanced primary tumours, and has been suggested to play an important role in tumour progression and the development of metastasis in certain human carcinomas.

Immunogen Sequence:This MCAM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-558 amino acids from the C-terminal region of human MCAM.

Target Alternative Name:MCAM; MUC18; Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen

Species Reactivities:Human.

Tag Line:Polyclonal Antibody to detect CD146 in human samples.

Formulation:In PBS with 0.09% (W/V) sodium azide.

Purification: Protein A column, followed by peptide affinity purification.

Application:Western blot, IHC.

Positive Control:Western blot: A2058 cell line lysate, IHC: human tonsil tissue.

Application And Usages:WB: 1:1000, IHC: 1:10 – 1:50.

Handling:The antibody solution should be gently mixed before use.