CBS Antibody (Center)

CBS Antibody (Center)is available at Gentaur for Next week Delivery.

Description: Strongly expressed in human liver and pancreas, with weaker expression in heart and brain, the cytoplasmic protein cystathionine b-synthase (CBS) operates in the first step of homocysteine transulfuration. CBS, which belongs to the cysteine synthase/cystathionine b-synthase family of proteins, catalyzes the formation of cystathionine from the thrombogenic amino acid homocysteine using pyridoxal phosphate cofactor. Allosteric activation by adenosyl-methionine regulates CBS activity. Deficiencies in CBS are associated with homocystinuria, a recessively inherited error in sulfur amino acid metabolism that affects many organs and tissues. Symptoms of homocytinuria include arteriosclerosis, thrombosis, dislocated optic lenses, mental retardation and skeletal abnormalities.

Immunogen Sequence:This CBS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 301-330 amino acids from the Central region of human CBS.

Target Alternative Name:CBS; Cystathionine beta-synthase; Beta-thionase; Serine sulfhydrase

Species Reactivities:Human and rat

Tag Line:Polyclonal Antibody to detect CBS in human and rat samples.

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Application:Western blot, IHC, FACS, IF

Positive Control:Western blot: Raji, Rat brain and cerebellum tissue lysate, IHC: human brain tissue, FACS: 293 cells, IF: 293 cells

Application And Usages:Western blot: ~1:1000, IHC: ~1:10–1:50, IF: ~1:10–1:50, FACS: ~1:10-1:50.

Handling:The antibody solution should be gently mixed before use.