Description
Caspase-8 Antibody (Clone C502S)is available at Gentaur for Next week Delivery.
Description: Caspase-8, a member of the caspase-family of proteases, plays a key role in mediating Fas (CD95) and TNF induced apoptosis. Caspase-8 is synthesized as inactive pro-enzyme and activation of the enzyme involves proteolytic cleavage that leads to the release of the active p18 and p10 subunits. Activated caspase-8 is able to cleave and activate downstream caspases, such as caspase-3, -6, -7 and a death agonist member of the Bcl-2/Bcl-xL family, Bid, leading to apoptosis.
Immunogen Sequence:Synthetic peptide derived from the amino-terminal sequence of p10 of human caspase-8
Target Alternative Name:CASP8 , mgC78473 , CASP-8, MACH, procaspase-8, MCH5, ALPS2B, FLICE, CAP4, EC 3.4.22.61
Species Reactivities:Human
Tag Line:/
Formulation:100 µg (200 µg/ml) affinity purified antibody in PBS containing 50% glycerol, 1% BSA, and 0.02% thimerosal.
Purification: Affinity purified
Application:Western blot, Immunoprecipitation
Positive Control:/
Application And Usages:Western blotting (0.5-4 µg/ml) and immunoprecipitation (10 µg/ml). However, the optimal conditions should be determined individually. Detects the 10 kDa small subunit of caspase-8. The antibody does not detect the full-length of caspase-8.
Handling:The antibody solution should be gently mixed before use.
Additional Information
Size: |
100 µg |
Antibody Target: |
Caspase-8 (Active) |
Category: |
Caspase |
Lot Number: |
51058 |
Host: |
Mouse |
Antibody Type: |
Monoclonal |
Isotype: |
Mouse IgG1 |
Accession Number: |
BC006737 |
Gene Id: |
12370 |
Concentration: |
0.2 μg/ml |
Appearance: |
Colorless liquid |
Form: |
Liquid |
Storage Condition: |
-20 °C |
Shipping Condition: |
gel pack |
Shelf Life: |
12 months |
Country of Animal Origin: |
USA |
Country of Manufacture: |
USA |
Usage: |
For Research Use Only! Not to be used in humans. |
Western Blot Verified: |
Verified |
Immunocytochemistry Verified: |
Not Verified |
Immunofluorescence Verified: |
Not Verified |
Immunoprecipitation Verified: |
Not Verified |
ELISA Verified: |
Not Verified |
ChIP Verified: |
Not Verified |
Flow Cytometry Verified: |
Not Verified |