Caspase-1 Antibody

Caspase-1 Antibodyis available at Gentaur for Next week Delivery.

Description: Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-1 (ICE, interleukin-1β-converting enzyme) is the mammalian caspase responsible for the proteolytic conversion of the proforms of interleukin-1β and IL-18 into active cytokines. Like other caspases, Caspase-1 itself is synthesized as a pro-enzyme that is cleaved during activation into a large (20 kDa) and small (10 kDa) subunits. The cellular role of caspase-1 appears limited to cytokine activation as they do not have obvious roles in apoptosis.

Immunogen Sequence:Synthetic peptide surrounding amino acid 132 of human caspase-1

Target Alternative Name:CASP1, IL1BCE, P45, Interleukin-1 beta convertase, IL-1BC, IL1BC, p45, IL1B-convertase, CASP-1, ICE

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:In phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.5 mM EDTA, 0.03% ProClin®

Purification: Affinity purified

Application:Western blot, Immunoprecipitation, Immunofluorescence

Positive Control:/

Application And Usages:Western blot analysis (0.5-4 µg/ml), immunoprecipitation (4-8 µg/ml) and immunofluorescence (10-20 µg/ml). The immunoaffinity purified antibody recognizes 45 kDa procaspase-1 and the 20 kDa cleaved product.

Handling:The antibody solution should be gently mixed before use.