BICC1 Antibody (NT)

BICC1 Antibody (NT)is available at Gentaur for Next week Delivery.

Description: BICC1, also known as protein bicaudal C homolog 1, is a 974 amino acid protein that belongs to the BICC family. BICC1 is considered a putative RNA-binding protein and may be involved in regulating gene expression during embryonic development by modulating protein translation. Existing as two alternatively spliced isoforms, BICC1 contains two KH domains as well as one SAM (sterile α motif) domain. Both BICC1 isoforms are widely expressed in normal tissues and are found in all brain regions including cerebral cortex, hippocampus and midbrain, although BICC1 isoform 1 is more highly expressed than isoform 2, particularly in nerve tissue. BICC1 can uncouple dishevelled-2 (Dvl-2) signaling from the canonical Wnt pathway in a SAM domain dependent manner, suggesting that the different BICC1 isoforms may play varying biological roles. Genetic variants in BICC1 may be involved in recurrent unipolar major depression. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

Immunogen Sequence:This BICC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-107 amino acids from the N-terminal region of human BICC1.

Target Alternative Name:BICC1; Protein bicaudal C homolog 1

Species Reactivities:Human

Tag Line:Polyclonal Antibody to detect BICC1 in human samples

Formulation:100 µl of antibody in PBS with 0.09% (W/V) sodium azide

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Application:Western blot, IHC

Positive Control:Western blot: HL60 cell lysate, IHC: human brain tissue

Application And Usages:Western blot: ~1:1000, IHC: ~1:10–1:50.

Handling:The antibody solution should be gently mixed before use.