APP Antibody (CT)

APP Antibody (CT)is available at Gentaur for Next week Delivery.

Description: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.

Immunogen Sequence:A peptide corresponding to the amino acids 737 to 751 of APP or 85 to 99 of the C99 fragment generated by b-secretase cleavage.

Target Alternative Name:amyloid-b-peptide, amyloid beta peptide, Amyloid beta A4 protein, Alzheimer disease amyloid protein, ABPP, APPI, Cerebral vascular amyloid peptide,

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:100 µg (1 mg/ml) in 1X PBS containing 0.02% sodium azide.

Purification: Affinity chromatography purified via peptide column.

Application:Western blot, Immunohistochemistry, ELISA

Positive Control:Mouse and rat brain tissue lysates

Application And Usages:Immunohistochemistry: 2 μg/ml; Western Blot: 1 – 2 μg/ml; ELISA. However, the optimal conditions should be determined individually.

Handling:The antibody solution should be gently mixed before use.