APG7/ATG7 Antibody

APG7/ATG7 Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is APG7 which was identified in yeast as a ubiquitin-E1-like enzyme; this function is conserved in the mammalian homolog (4). In mammalian cells, APG7 is essential for autophagy conjμgation systems, autophagosome formation, starvation-induced bulk degradation of proteins and organelles. It has been sμggested that caspase-8 may alter APG7 levels and thus the APG7 program of autophagic cell death.

Immunogen Sequence:Synthetic peptide near the N-terminus of rat APG7

Target Alternative Name:APG7L , ATG7 , DKFZp434N0735 , GSA7

Species Reactivities:Human, mouse

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Formulation:0.5 mg/ml affinity purified rabbit anti-APG7/ATG7 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined.

Handling:The antibody solution should be gently mixed before use.