APG16/ATG16 Antibody

APG16/ATG16 Antibodyis available at Gentaur for Next week Delivery.

Description: Autophagy, the process of bulk degradation of cellular proteins throμgh an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) throμgh phosphorylation of autophagy protein APG1. ATG16, another member of the autophagy protein family, forms a complex with the ATG5-ATG12 conjμgate. This multimeric protein has been shown to be essential for autophagosome formation in both yeast and mammals and targets the ATG5-ATG12 complex to the autophagic isolation membrane during the formation of the autophagosome. Because mammalian ATG16 has seven WD-repeats in its C-terminal domain, it has been sμggested that these may form a platform for further protein-protein interactions. Multiple isoforms of ATG16 are known to exist.

Immunogen Sequence:Synthetic peptide surrounding amino acid 565 of human APG16

Target Alternative Name:APG16 , APTG 16

Species Reactivities:Human, mouse, rat

Tag Line:/

Formulation:0.5 mg/ml affinity purified rabbit anti-APG16 in PBS containing 30% glycerol, 0.5 mg/ml BSA and 0.01% thimerosal.

Purification: Affinity purified

Application:Western blot

Positive Control:/

Application And Usages:Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Other applications have not been determined.

Handling:The antibody solution should be gently mixed before use.