Anti-TNFSF11 (Denosumab), Human IgG2 Antibody

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SKU:
A2150-100
£332.93
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Description

Anti-TNFSF11 (Denosumab), Human IgG2 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a fully human IgG2 monoclonal antibody that specifically targets receptor activator of nuclear factor kappa-B ligand (RANKL), a protein that plays a key role in the formation, function, and survival of osteoclasts. RANKL belongs to the TNF superfamily of ligands. Interaction with the receptor (RANK) expressed on pre-osteoclast and mature osteoclast cells results in the activation, migration, differentiation, and fusion of hematopoietic cells of osteoclast lineage, and promotes bone resorption. By preventing the RANKL-RANK interaction, the antibody inhibits bone resorption and increases bone mass density and strength, thus decreasing the risk of hip, vertebral, and non-vertebral fractures. The original monoclonal antibody received approval from the FDA for the treatment of osteoporosis in postmenopausal women, and to treat patients with bone metastases

Immunogen Sequence:Human TNFSF11

Target Alternative Name:CD254, ODF, OPGL, sOdf, OPTB2, RANKL, TNLG6B, TRANCE, hRANKL2

Species Reactivities:Human

Tag Line:The biosimilar is a human monoclonal antibody that targets RANKL and inhibits the binding to its receptor RANK, thus reducing bone resorption and increasing bone mass and strength.

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
TNFSF11
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
IgG2, kappa
Accession Number:
DB06643
Concentration:
Lot specific
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
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Immunocytochemistry Verified:
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Immunofluorescence Verified:
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Immunoprecipitation Verified:
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FACS Verified:
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ELISA Verified:
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