Anti-TNF-α (Certolizumab), Humanized Antibody

Anti-TNF-α (Certolizumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a humanized TNF-α monoclonal antibody. The original monoclonal antibody (Certolizumab pegol (CZP)) consists of polyethylene glycol conjugated to the antigen-binding fragment of the humanized monoclonal antibody. The antibody targets and neutralizes soluble and membrane forms of tumor necrosis factor-alpha (TNF-α) and inhibits TNF-α mediated signaling in vitro. Unlike other TNF inhibitors, this antibody does not contain the Fc region. As a result, decreased Fc-mediated effects such as antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) are observed. The original monoclonal antibody received FDA approval to treat moderate to severe rheumatoid arthritis, Crohn’s disease, ankylosing spondylitis, and psoriatic arthritis.

Immunogen Sequence:Certolizumab

Target Alternative Name:TNFSF2, TNF-alpha, TNFA, TNF-α, TNFα

Species Reactivities:Human

Tag Line:A humanized monoclonal antibody that targets and inhibits soluble and membrane forms of TNF-α

Formulation:In PBS, pH 7.5

Purification: Protein A purified

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Handling:The antibody solution should be gently mixed before use.