Anti-TNF alpha (Infliximab), Human IgG1 Antibody

Anti-TNF alpha (Infliximab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line.

Immunogen Sequence:Purified recombinant human TNF (rTNF)

Target Alternative Name:TNF-α; TNFα; TNFSF; Tumor necrosis factor; Cachectin; TNF-alpha; Tumor necrosis factor ligand superfamily member 2; TNF-a; TNFa

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect TNF alpha in human samples.

Formulation:200 µg affinity purified human antibody in phosphate-buffered saline (PBS) containing 0.02% Proclin 300

Purification: Affinity purified using protein A

Application:ELISA; in vivo; FC

Positive Control:N/A

Application And Usages:/

Handling:The antibody solution should be gently mixed before use