Anti-TIF1 gamma Antibody (3H7-C8-B9)

Anti-TIF1 gamma Antibody (3H7-C8-B9)is available at Gentaur for Next week Delivery.

Description: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade)

Immunogen Sequence:Recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli.

Target Alternative Name:ECTO, PTC7, RFG7, TF1G, TIF1G, TIF gamma, TIF1gamma

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect TIF1γ/TRIM33

Formulation:In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Purification: Affinity purified

Application:WB

Positive Control:WB: MCF7 and HeLa nuclear extracts

Application And Usages:WB; 1:1000

Handling:The antibody solution should be gently mixed before use