Anti-SOST (Romosozumab), Humanized Antibody

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SKU:
A2219-100
€465
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Description

Anti-SOST (Romosozumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a humanized IgG2 monoclonal antibody that specifically targets Sclerostin (SOST). Sclerostin is a glycoprotein secreted by the osteocytes during the remodeling of the bone. It binds to LRP5/6, a Wnt co-receptor, inhibits Wnt signaling pathway and bone formation. The antibody binds to and inhibits Sclerostin, thus releasing the inhibitory effect on Wnt signaling and enabling bone formation. The original antibody was approved by the FDA to treat postmenopausal women with osteoarthritis and patients that are at a high risk of fracture or have failed therapy for osteoporosis

Immunogen Sequence:Human SOST

Target Alternative Name:CDD, VBCH, DAND6, SOST1, Sclerostin, SOST, Sclerosteosis, AMG 785, CDP 7851, 785A070802

Species Reactivities:Human

Tag Line:The biosimilar is a humanized monoclonal antibody that binds to and inhibits Sclerostin, thus activating WNT signaling pathway and promoting bone formation

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
SOST
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
IgG2, kappa
Accession Number:
DB11866
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
FAUX
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
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ELISA Verified:
FAUX
ChIP Verified:
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Dot Blot Verified:
FAUX
Flow Cytometry Verified:
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