Anti-SOST (Romosozumab), Humanized Antibody

Anti-SOST (Romosozumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a humanized IgG2 monoclonal antibody that specifically targets Sclerostin (SOST). Sclerostin is a glycoprotein secreted by the osteocytes during the remodeling of the bone. It binds to LRP5/6, a Wnt co-receptor, inhibits Wnt signaling pathway and bone formation. The antibody binds to and inhibits Sclerostin, thus releasing the inhibitory effect on Wnt signaling and enabling bone formation. The original antibody was approved by the FDA to treat postmenopausal women with osteoarthritis and patients that are at a high risk of fracture or have failed therapy for osteoporosis

Immunogen Sequence:Human SOST

Target Alternative Name:CDD, VBCH, DAND6, SOST1, Sclerostin, SOST, Sclerosteosis, AMG 785, CDP 7851, 785A070802

Species Reactivities:Human

Tag Line:The biosimilar is a humanized monoclonal antibody that binds to and inhibits Sclerostin, thus activating WNT signaling pathway and promoting bone formation

Formulation:In PBS, pH 7.5

Purification: Protein A purified

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Handling:The antibody solution should be gently mixed before use.