Anti-SARS-CoV-2 ORF7a Antibody

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SKU:
A2259-100
£340.25
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Description

Anti-SARS-CoV-2 ORF7a Antibodyis available at Gentaur for Next week Delivery.

Description: Severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) is an infectious disease caused by a novel beta-coronavirus called SARS-CoV-2. The SARS-CoV-2 is a large enveloped, positive-sense RNA with a genome about ~ 30 kb long. The genome encodes 11 open reading frames. The open reading frame ORF7a is a type I transmembrane protein that codes for viral non-structural (accessory) proteins of unknown function. It is localized to the Golgi apparatus but may also be found on cell surfaces. In comparison with ORF7a of SARS-CoV, it has a sequence identity of 85.2% and a sequence similarity of 95.9%. Due to overlap with ORF7b, ORF7a shares a transcriptional regulatory sequence. ORF7a possesses a 15 amino acid N-terminal signal peptide, an 81 amino acid luminal domain, a 21 amino acid transmembrane domain, and a 5 amino acid cytoplasmic tail. A recent study demonstrated that SARS-CoV ORF7a acts as an antagonist to Bone marrow stromal antigen 2 (BST-2) antiviral activities. ORF7a extracellular domain binds to the unglycosylated extracellular domain of BST-2 in the Golgi apparatus and prevents N-linked glycosylation that is necessary for BST-2 antiviral activity.

Immunogen Sequence:Amino acids 1-100 of ORF7a protein

Target Alternative Name:ORF7a, Accessory protein 7a, Protein U122, Protein X4, ORF7a protein

Species Reactivities:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Tag Line:Rabbit polyclonal antibody to detect SARS-CoV-2 ORF7a protein

Formulation:In PBS, pH 7.4, 50% glycerol, 0.05% proclin 300

Purification: /

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
ORF7a
Category:
Primary antibody
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
IgG
Accession Number:
P0DTC7
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 to -80°C
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
FAUX
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
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ELISA Verified:
FAUX
ChIP Verified:
FAUX
Dot Blot Verified:
FAUX
Flow Cytometry Verified:
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