Anti-Phospho-ERK1/2 (Thr202/Tyr204) Antibody

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SKU:
A1589-100
$1,535.31
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Description

Anti-Phospho-ERK1/2 (Thr202/Tyr204) Antibodyis available at Gentaur for Next week Delivery.

Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis.

Immunogen Sequence:A synthesized peptide derived from human ERK1/2 around the phosphorylation site of Threonine 202/Tyrosine 204

Target Alternative Name:Mitogen-activated protein kinase 3, MAP kinase 3, MAPK 3, ERK-1, Extracellular signal-regulated kinase 1, ERK-1

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of ERK1/2 (pThr202/Tyr204) in human, mouse and rat samples

Formulation:In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol

Purification: Affinity purified

Application:WB, IHC, IF

Positive Control:WB: HeLa cell lysate, IHC: human small instestinal carcinoma, IF: lovo cells

Application And Usages:WB; 1:500 – 1:2000, IHC; 1:50- 1:200, IF; 1-200

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
Mitogen-activated protein kinase 3
Category:
Signal Transduction
Host:
Rabbit
Antibody Type:
Polyclonal
Isotype:
Rabbit IgG
Accession Number:
P27361
Gene Id:
5595
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20 °C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
Verified
Immunocytochemistry Verified:
Verified
Immunofluorescence Verified:
Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Not Verified
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