Anti-PAX-8 Antibody (IHC008)

Anti-PAX-8 Antibody (IHC008)is available at Gentaur for Next week Delivery.

Description: PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.

Immunogen Sequence:PAX-8

Target Alternative Name:Paired box protein Pax-8, PAX8, paired box 8, paired box gene 8

Species Reactivities:Human

Tag Line:Monoclonal Antibody to detect PAX-8 in human samples

Formulation:Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide

Purification: Protein A/G purification

Application:IHC

Positive Control:IHC: Thyroid Carcinoma

Application And Usages:IHC: 1:100 - 1:200

Handling:The antibody solution should be gently mixed before use