Anti-NOTCH 2 Antibody

Anti-NOTCH 2 Antibodyis available at Gentaur for Next week Delivery.

Description: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells.

Immunogen Sequence:KLH-conjugated synthetic peptide encompassing a sequence within the center region of human NOTCH2

Target Alternative Name:Neurogenic locus notch homolog protein 2; Notch 2; hN2

Species Reactivities:Human, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of NOTCH 2 in human and rat samples

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: HeLa; MCF7; rat liver; NIH3T3 whole cell lysates

Application And Usages:WB; 1:500 – 1:1000, IH; 1:100 – 1:200

Handling:The antibody solution should be gently mixed before use.