Anti-mTOR Rabbit Monoclonal Antibody

Anti-mTOR Rabbit Monoclonal Antibody is available at Gentaur for Next week Delivery.

Description: The mammalian target of rapamycin (mTOR, FRAP, RAFT) is a Ser/Thr protein kinase that functions as an ATP and amino acid sensor to balance nutrient availability and cell growth. When sufficient nutrients are available, mTOR responds to a phosphatidic acid-mediated signal to transmit a positive signal to p70 S6 kinase and participate in the inactivation of the eIF4E inhibitor, 4E-BP1. These events result in the translation of specific mRNA subpopulations. mTOR is phosphorylated at Ser2448 via the PI3 kinase/Akt signaling pathway and autophosphorylated at Ser2481. mTOR plays a key role in cell growth and homeostasis and may be abnormally regulated in tumors. For these reasons, mTOR is currently under investigation as a potential target for anti-cancer therapy.

Immunogen Sequence:A peptide corresponding to human serine/threonine-protein kinase mTOR

Target Alternative Name:FRAP1, FK506 binding protein 12-rapamycin associated protein 1; FRAP2, FK506 binding protein 12-rapamycin associated protein 2; RAFT1, RAPT1

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect mTOR in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: breast cancer tissue, WB: HeLa cell lysate

Application And Usages:WB: 1:1000-1:2000 IHC: 1:500-1:1000

Handling:The antibody solution should be gently mixed before use.