Anti-KDM5C / Jarid1C / SMCX Antibody

Anti-KDM5C / Jarid1C / SMCX Antibodyis available at Gentaur for Next week Delivery.

Description: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2

Immunogen Sequence:Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli

Target Alternative Name:MRXJ, SMCX, MRXSJ, XE169, MRXSCJ, JARID1C, DXS1272E, Lysine-specific demethylase 5C, Jumonji/ARID domain-containing protein 1C

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect KDM5C / Jarid1C / SMCX

Formulation:In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol

Purification: Affinity purified

Application:WB, IF

Positive Control:WB: HeLa, 293, T$7D, MCF7 cell lysates; IF: HeLa cells

Application And Usages:WB; 1:1000; IF; 1:150

Handling:The antibody solution should be gently mixed before use