Anti-Islet-1 Antibody

Anti-Islet-1 Antibodyis available at Gentaur for Next week Delivery.

Description: DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart.

Immunogen Sequence:Recombinant full length protein of human Islet-1

Target Alternative Name:Insulin gene enhancer protein ISL-1; Islet-1

Species Reactivities:Human, Mouse, Rat

Tag Line:Polyclonal antibody to detect endogenous levels of Islet-1 in human, mouse and rat samples

Formulation:In 0.42% Potassium phosphate; 0.87% Sodium chloride; pH 7.3; 30% glycerol and 0.01% sodium azide

Purification: Affinity purified

Application:WB, IF

Positive Control:WB: Hela; mouse thymus; rat thymus whole cell lysates, IF/ICC: A549 cells

Application And Usages:WB; 1:500 – 1:2000, IF/IC; 1:50 – 1:200

Handling:The antibody solution should be gently mixed before use.