Anti-IL-6 (Siltuximab), Chimeric Antibody

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SKU:
A2143-100
£332.93
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Description

Anti-IL-6 (Siltuximab), Chimeric Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a chimeric (human-murine) IgG1 kappa monoclonal antibody produced in Chinese Hamster Ovary (CHO) cells. This antibody binds to and neutralizes human IL-6, inhibits IL-6 binding to its receptor, and subsequent IL-6 signaling. The original monoclonal antibody received FDA approval to treat patients suffering from multicentric Castleman’s disease and negative for HIV and HHV-8. This monoclonal antibody has recently been investigated for the treatment of various forms of cancer such as metastatic renal cell cancer, ovarian cancer, and prostate cancer.

Immunogen Sequence:Siltuximab

Target Alternative Name:CDF, HGF, HSF, BSF2, IL-6, BSF-2, IFNB2, IFN-beta-2, IL6

Species Reactivities:Human

Tag Line:A chimeric monoclonal antibody that targets and prevents the binding of human IL-6 with its receptors, which results in decreased lymphocyte proliferation

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
IL-6
Category:
Biosimilars
Host:
Human/Mouse chimeric
Antibody Type:
Monoclonal
Isotype:
IgG1, kappa
Accession Number:
DB09036
Concentration:
Lot specific
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
FAUX
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
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ELISA Verified:
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ChIP Verified:
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Dot Blot Verified:
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Flow Cytometry Verified:
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