Anti-IL-4Rα (Dupilumab), Human IgG4 Antibody

Anti-IL-4Rα (Dupilumab), Human IgG4 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a fully human IgG4 monoclonal antibody that targets IL-4Rα and inhibits IL-4 and IL-13 signaling. Both IL-4 and IL-13 play an important role in Th-2 mediated immune response. Their inhibition leads to reduced Type 2 inflammation. The biosimilar was generated in CHO cells using recombinant DNA technology. The original monoclonal antibody received approval from the FDA for the treatment of atopic dermatitis and eczema. Additionally, this antibody received approval to treat patients aged 12 years and above, suffering from moderate-to-severe asthma, and moderate-to-severe eosinophilic asthma, or oral corticosteroid-dependent asthma.

Immunogen Sequence:Human IL-4Rα

Target Alternative Name:CD124, IL4RA, IL-4RA, IL4R

Species Reactivities:Human

Tag Line:A fully human monoclonal antibody that binds to the IL-4 receptor and inhibits receptor-mediated signaling of pro-inflammatory cytokines that play a central role in inflammatory and allergic conditions such as asthma, eczema, and rhinosinusitis

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:In vitro studies

Positive Control:/

Application And Usages:In vitro studies

Handling:The antibody solution should be gently mixed before use.