Anti-IL-17Rα (Brodalumab), Human IgG2 Antibody

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SKU:
A2155-100
$1,768.52
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Description

Anti-IL-17Rα (Brodalumab), Human IgG2 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a recombinant, fully human IgG2 kappa monoclonal antibody that binds with a high affinity to the Interleukin-17 receptor α (IL-17Rα). IL-17R is a type I membrane glycoprotein that is ubiquitously expressed on cell surfaces and binds IL17α with low affinity. IL17α plays an important role in the pathogenesis of inflammatory and autoimmune diseases such as rheumatoid arthritis. The antibody binds to the IL-17Rα and inhibits IL-17 induced release of pro-inflammatory cytokines and chemokines such as NF-κB, IL-6, IL-8, COX-2, MMPs, and GM-CSF. The original drug received approval from the FDA to treat moderate-to-severe psoriasis

Immunogen Sequence:Human IL-17Rα

Target Alternative Name:AMG827, KHK4827, AMG 827, AMG-827, KHK-4827, KHK4827, IL17RA, CD217

Species Reactivities:Human

Tag Line:The biosimilar is a human monoclonal antibody that targets IL-17Rα and inhibits the release of pro-inflammatory cytokines and chemokines. The original drug is approved by the FDA to treat plaque psoriasis

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
100 µg
Antibody Target:
IL-17Rα
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
Human IgG2, kappa
Accession Number:
DB11776
Concentration:
1 mg/ml
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
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