Anti-IL-12β (Ustekinumab), Human IgG1 Antibody

Anti-IL-12β (Ustekinumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a human IgG1κ monoclonal antibody that was generated using human immunoglobulin (hu-Ig) transgenic mice. This monoclonal antibody specifically binds to the p40 subunit of IL-12 and IL-23, thus preventing their association with the IL-12Rβ1 receptor expressed on the NK cell and T cell surface and resulting in reduced IL-12 and IL-23 mediated signaling, activation, and cytokine production. The original monoclonal antibody was developed by Centocor and received FDA approval in 2009 for use in the treatment of psoriasis. Recently, it has been approved for the treatment of Crohn’s disease and ulcerative colitis.

Immunogen Sequence:Ustekinumab

Target Alternative Name:IL-12β, IL12β, IL 12β

Species Reactivities:Human

Tag Line:A human monoclonal antibody that targets IL-12 and IL-23 by inhibiting their interaction with the receptor IL-12Rβ1 and thus disrupting IL-12 and IL-23 mediated signaling that is central to inflammatory diseases

Formulation:In PBS pH 7.5

Purification: Protein A purified

Application:In vitro studies

Positive Control:/

Application And Usages:In vitro studies

Handling:The antibody solution should be gently mixed before use.