Anti- Histone H3.3 Rabbit Monoclonal Antibody

Anti- Histone H3.3 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Immunogen Sequence:A peptide corresponding to human Histone H3.3.

Target Alternative Name:H3F3A, H3.3A, H3F3, H3F3B, H3.3B

Species Reactivities:Human

Tag Line:Rabbit monoclonal antibody to detect Histone H3.3.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified using protein A

Application:WB, ELISA, Multiplex

Positive Control:WB: Hela cell lysate

Application And Usages:Western Blot: 0.5 ug/mL – 2 ug/mL; ELISA: 0.2 ug/mL - 1 ug/mL; Multiplex: 0.05 ug/mL – 0.5 ug/mL.

Handling:The antibody solution should be gently mixed before use.