Anti-HER2 (Pertuzumab), Humanized Antibody

Anti-HER2 (Pertuzumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: Pertuzumab is a humanized monoclonal antibody that is produced by recombinant DNA technology in CHO cells and targets the extracellular domain of human epidermal growth factor receptor 2 (HER2) by blocking the binding pocket required for dimerization of the receptor and receptor mediated signaling. This prevents binding of HER2 with other HER family members (HER1, HER3, HER4) and thus inhibits cancer cell growth. Developed by Roche and Genentech, Pertuzumab was approved by FDA in 2012 to treat advanced breast cancer. Combination treatment with Trastuzumab and Docetaxel has been recommended for treating patients that have HER2-positive metastatic breast cancer.

Immunogen Sequence:Pertuzumab

Target Alternative Name:2C4, rhuMAb-2C4, HER2, HER-2, HER 2, Neu, Ngl, Erbb2, Tkr1, Cd340, Mln 19, HER-2/neu

Species Reactivities:/

Tag Line:Pertuzumab is a humanized monoclonal antibody that binds to HER2 receptor and inhibits the binding of HER2 to other HER family members (HER1, HER3, HER4) on cancer cell surface

Formulation:In PBS buffer, pH 7.2

Purification: /

Application:Growth inhibition assay, Cell cytotoxicity assay, In vivo studies

Positive Control:/

Application And Usages:Growth inhibition assay, Cell Cytotoxicity assay, In vivo studies

Handling:The antibody solution should be gently mixed before use.