Anti-HER2 (Margetuximab), Chimeric Antibody

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SKU:
A2284-50
  • Anti-HER2 (Margetuximab), Chimeric Antibody
  • Anti-HER2 (Margetuximab), Chimeric Antibody
$292
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Description

Anti-HER2 (Margetuximab), Chimeric Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar is a chimeric IgG1 monoclonal antibody targeted against HER2/ERBB2. The original monoclonal antibody is derived from the parent antibody (Trastuzumab). Both antibodies bind efficiently to the same epitope of HER2 and mediate similar effects on cancer cells. However, in contrast to Trastuzumab, the Fc region of this monoclonal antibody is modified to increase the binding to CD16A and reduced binding to CD32B. Increased binding to CD16A leads to increased antibody-dependent cellular cytotoxicity (ADCC). The monoclonal antibody binds to the extracellular domain of HER2 expressed on tumor cells, inhibits tumor growth, and promotes ADCC. The original antibody received FDA approval to treat patients with metastatic HER2 cancer either alone or in combination with chemotherapy

Immunogen Sequence:Human HER2

Target Alternative Name:NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19; HER-2/neu, ERBB2, EC 2.7.10.1, Herstatin, P185erbB2, EC 2.7.10, MLN19

Species Reactivities:Human

Tag Line:The biosimilar is a chimeric monoclonal antibody that targets HER2

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:/

Positive Control:/

Application And Usages:/

Handling:The antibody solution should be gently mixed before use.

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Additional Information

Size:
50 µg
Antibody Target:
HER2
Category:
Biosimilars
Host:
Recombinant
Antibody Type:
Monoclonal
Isotype:
IgG1, kappa
Accession Number:
DB14967
Gene Id:
2064
Concentration:
Lot specific
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-80ºC
Shipping Condition:
Gel Pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans.
Western Blot Verified:
FAUX
Immunocytochemistry Verified:
FAUX
Immunofluorescence Verified:
FAUX
Immunoprecipitation Verified:
FAUX
FACS Verified:
FAUX
ELISA Verified:
FAUX
ChIP Verified:
FAUX
Dot Blot Verified:
FAUX
Flow Cytometry Verified:
FAUX
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