Anti-HA (H5N1) Monoclonal Antibody

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SKU:
A1240-100
€295
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Description

Anti-HA (H5N1) Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. The recombinant HA protein of a clade H5N1 virus was used to generate monoclonal antibodies for viral neutralization assays. The HA full-length protein was expressed in insect cells infected with baculovirus carrying the HA gene to ensure that it underwent glycosylation.

Immunogen Sequence:HA full length that was expressed and purified from insect cells

Target Alternative Name:/

Species Reactivities:/

Tag Line:Monoclonal antibody to detect HA (H5N1)

Formulation:/

Purification: /

Application:FC, IF, WB

Positive Control:WB: 293T cells transfected with a cDNA construct expressing Hatay04 HA; IF: MDCK cells transfected with DL06-HA or Hatay04-HA expressing plasmids

Application And Usages:/

Handling:The antibody solution should be gently mixed before use

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Additional Information

Size:
100 µg
Antibody Target:
HA
Lot Number:
N/A
Host:
Mouse
Antibody Type:
Monoclonal
Isotype:
Mouse IgG2b
Accession Number:
C0LYC6
Gene Id:
956529
Appearance:
Colorless liquid
Form:
Liquid
Storage Condition:
-20°C
Shipping Condition:
gel pack
Shelf Life:
12 months
Country of Animal Origin:
USA
Country of Manufacture:
USA
Usage:
For Research Use Only! Not to be used in humans
Western Blot Verified:
Not Verified
Immunocytochemistry Verified:
Not Verified
Immunofluorescence Verified:
Verified
Immunoprecipitation Verified:
Not Verified
FACS Verified:
Not Verified
ELISA Verified:
Not Verified
ChIP Verified:
Not Verified
Dot Blot Verified:
Not Verified
Flow Cytometry Verified:
Verified
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