Anti-EGFR (Matuzumab), Human IgG1 Antibody

Anti-EGFR (Matuzumab), Human IgG1 Antibodyis available at Gentaur for Next week Delivery.

Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin.

Immunogen Sequence:Domain III of the extracellular domain of human EGFR

Target Alternative Name:Epidermal Growth Factor Receptor, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect EGFR in human samples.

Formulation:Supplied in PBS, pH 7.5

Purification: SOURCE: CHO cells

Application:Block; FC; WB

Positive Control:N/A

Application And Usages:/

Handling:The antibody solution should be gently mixed before use