Anti-Dabigratan (Idarucizumab), Humanized Antibody

Anti-Dabigratan (Idarucizumab), Humanized Antibodyis available at Gentaur for Next week Delivery.

Description: The research-grade biosimilar antibody is a humanized monoclonal antibody fragment that specifically neutralizes the anti-coagulatory effect of dabigatran. Dabigatran is a non-peptidic inhibitor of thrombin (Factor IIa) that plays an important role in blood coagulation. Dabigatran and its acyl glucuronide metabolites bind reversibly with thrombin and inhibit its coagulatory activity. The antibody binds to thrombin-bound dabigatran and its metabolites in a 1:1 ratio with very high affinity (≈ 350-fold higher than dabigatran affinity for thrombin) and thus prevents thrombin inhibition. The original drug was approved by the FDA to treat patients requiring emergency surgery or having an uncontrolled bleeding condition

Immunogen Sequence:Dabigatran etexilate mesylate

Target Alternative Name:aDabi-Fab, BI 655075, BI-655075, BI655075, dabigatran etexilate mesylate

Species Reactivities:/

Tag Line:The biosimilar is a humanized monoclonal antibody that binds to dabigatran and prevents its anticoagulatory effect in patients with an uncontrolled bleeding condition or those requiring surgery/urgent procedures

Formulation:In PBS, pH 7.5

Purification: Protein A purified

Application:In vitro studies

Positive Control:/

Application And Usages:In vitro studies

Handling:The antibody solution should be gently mixed before use.