Anti-Cyclin H Antibody (1H9-D3-E11)

Anti-Cyclin H Antibody (1H9-D3-E11)is available at Gentaur for Next week Delivery.

Description: Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.

Immunogen Sequence:Recombinant human Cyclin H protein fragments expressed in E.coli

Target Alternative Name:Cyclin-H, MO15-associated protein, p34, p37

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect Cyclin H

Formulation:In buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol

Purification: Affinity purified

Application:WB, IP

Positive Control:WB: Jurkat, K562 and A431 cell lysates; IP: HeLa cell lysates

Application And Usages:WB; 1:1000, IP

Handling:The antibody solution should be gently mixed before use