Anti-CPS1 Antibody (CPS1/1022)

Anti-CPS1 Antibody (CPS1/1022)is available at Gentaur for Next week Delivery.

Description: This mAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC occurs primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

Immunogen Sequence:Recombinant human CPS1 protein

Target Alternative Name:Carbamoyl-phosphate synthetase 1 (CPS1); Carbamoylphosphate synthetase 1; CPSase 1; CPSASE1

Species Reactivities:Human, Dog

Tag Line:Monoclonal Antibody to detect CPS1 in human samples

Formulation:Supplied in 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purified

Application:IF, IHC

Positive Control:IHC: human Hepatocellular Carcinoma

Application And Usages:IF: 0.5-1.0 µg/ml, IHC: 0.25-0.5 µg/ml for 30 minutes at RT

Handling:The antibody solution should be gently mixed before use