Anti-CD63 Antibody (Clone NKI/C3)

Anti-CD63 Antibody (Clone NKI/C3)is available at Gentaur for Next week Delivery.

Description: This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of mAb LAMP3/529. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.

Immunogen Sequence:Smooth plasma membrane fraction of MeWo cells

Target Alternative Name:gp55; granulophysin; Lysosomal-associated membrane protein 3 (LAMP-3); Mast cell antigen AD1; melanoma 1 antigen; Melanoma-associated antigen MLA1; Melanoma-associated antigen ME491; MLA1; NGA; Ocular melanoma-associated antigen; OMA81H; PTLGP40; Tetraspanin-30; TSPAN30; CD63

Species Reactivities:Human and Mouse

Tag Line:Monoclonal Antibody to detect CD63 in human samples

Formulation:In 10 mM PBS with 0.05% BSA & 0.05% azide

Purification: Protein A/G purification

Application:FC, IF, WB, IHC

Positive Control:WB: Human Spleen, IHC: Human melanoma, Mouse Spleen, FC: human CD63 on MCF-7 Cells

Application And Usages:FC: 0.5-1 µg/1X106 cells in 0.1 ml, IF: 0.5-1 µg/ml, WB: 0.5-1 µg/ml, IHC: 0.5-1 µg/ml for 30 minutes at RT

Handling:The antibody solution should be gently mixed before use