Anti-CD45 Rabbit Monoclonal Antibody

Anti-CD45 Rabbit Monoclonal Antibodyis available at Gentaur for Next week Delivery.

Description: CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phospho-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Immunogen Sequence:A peptide corresponding to the C-terminus of human CD45 (Receptor-type tyrosine-protein phosphatase C)

Target Alternative Name:B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Species Reactivities:Human

Tag Line:Monoclonal antibody to detect CD45 in human samples.

Formulation:In 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

Purification: Affinity purified

Application:WB, IHC

Positive Control:WB: Jurkat cell lysate, IHC: tonsil tissue section

Application And Usages:WB: 1:1000-1:2000, IHC: 1:100-1:200

Handling:The antibody solution should be gently mixed before use.